یک مطالعه مقطعی
بررسی ارتباط بین چربی اپیکاردیال، نمره کلسیم شریانهای کرونر و بیماری کبد چرب غیرالکلی از طریق سیتیاسکن قفسه سینه غیر ECG-gated
بیماری شریان کرونر (CAD) یک مشکل بزرگ بهداشت جهانی است که حدود ۲۰٪ از مرگهای سالانه را به خود اختصاص میدهد. چربی اپیکاردیال (EAT) که در اطراف قلب قرار دارد، میتواند تأثیرات مفید و مضری داشته باشد و بر توسعه CAD از طریق سیتوکینهای التهابی تأثیر بگذارد. با پیشرفت CAD، نمره کلسیم شریانهای کرونر (CACS) برای ارزیابی ریسک بیماریهای قلبی اهمیت پیدا میکند. این مطالعه به بررسی ارتباطات بین ویژگیهای EAT، بیماری کبد چرب غیرالکلی (NAFLD) و CACS با استفاده از سیتیاسکن قفسه سینه غیر ECG-gated بدون کنتراست میپردازد و یک روش غیرتهاجمی و مقرونبهصرفه برای درک بهتر مکانیزمهای بیماریهای قلبی ارائه میدهد.
Exploring the interplay between epicardial fat, coronary artery calcium score, and nonalcoholic fatty liver disease through non-ECG-gated chest computed tomography: A cross-sectional study
Abstract
Background and aims: This study examines the relationships between epicardial adipose tissue (EAT), nonalcoholic fatty liver disease (NAFLD), and coronary artery calcium score (CACS) using non-ECG-gated CT scans. It aims to determine the effectiveness of EAT measurements and NAFLD as predictors for coronary artery disease (CAD).
Methods: This cross-sectional study was conducted at a specialized center, focusing on individuals who underwent non-ECG-gated chest CT scans without contrast. We evaluated EAT thickness and density in three areas: the right atrioventricular groove, the free wall of the right ventricle, and the central area of the right anterior interventricular groove. Additionally, we measured CACS and determined the presence of NAFLD by comparing liver-to-spleen density ratios. Statistical analyses, including regression models, were performed using SPSS (version 26).
Results: In this study, we enrolled 365 participants, including 203 males with an average age of 47 ± 17.93 years. EAT thickness was 6.28 ± 1.62 mm, and EAT density was -96.07 ± 12.47 Hounsfield units (HU). The mean CACS was 22.27 ± 79.01, and the mean liver density was 50.01 ± 10.76 HU. A significant positive correlation was observed between EAT thickness and CACS (r = 0.208, p < 0.001). EAT density showed a significant negative correlation with CACS (r = -0.155, p = 0.003). No correlation was found between NAFLD and CACS. Univariate logistic regression analysis identified significant predictors of increased CACS, including EAT thickness (OR: 1.803), EAT density (OR: 0.671), diabetes mellitus (DM) (OR: 5.921), and hypertension (HTN) (OR: 7.414). Multivariate analysis confirmed the significance of EAT thickness (OR: 0.682), DM (OR: 3.66), and HTN (OR: 2.79) as predictors of elevated CACS.
Conclusion: Our findings demonstrate that increased EAT thickness and decreased density are associated with higher CACS. Also, both DM and HTN significantly contribute to increased CACS. These results support the inclusion of EAT measurements in cardiovascular risk assessment models to enhance diagnostic accuracy.
Keywords: computed tomography; coronary artery calcification; epicardial adipose tissue; nonalcoholic fatty liver disease.
© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
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